Phosphopantetheine-binding protein
Phosphopantetheine, also known as 4'-phosphopantetheine, is a prosthetic group of several acyl carrier proteins including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, the peptidyl carrier proteins (PCP), as well as aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS). It is also present in formyltetrahydrofolate dehydrogenase. WebFeb 1, 2024 · The reaction mechanism of PPAT involves a nucleophilic attack by 4′-phosphate of phosphopantetheine on the α-phosphate of ATP in an in-line displacement mechanism, where both the substrates are positioned in a single line. This results in a short lived intermediate pentacovalent transition state.
Phosphopantetheine-binding protein
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Webprotein Summary Phosphopantetheine-binding protein (Streptomyces rimosus subsp. rimosus ATCC 10970) Cite Download Contents 1 Sequence 2 Interactions and Pathways 3 … WebOct 23, 2013 · The results suggest that some type I domains covalently incorporated in multidomain contexts possess potential protein binding sites missing in the equivalent regions of their respective structural templates. ... This 1136 residue long sequence is atypical since it does not possess a recognizable phosphopantetheine binding domain …
WebThe acyl carrier protein ( ACP) is a cofactor of both fatty acid and polyketide biosynthesis machinery. It is one of the most abundant proteins in cells of E. coli. [1] In both cases, the … WebJul 1, 2003 · Phosphopantetheine adenylyltransferase (PPAT) regulates the key penultimate step in the essential coenzyme A (CoA) biosynthetic pathway. PPAT catalyzes the reversible transfer of an adenylyl group from Mg2+:ATP to 4′-phosphopantetheine to form 3′-dephospho-CoA (dPCoA) and pyrophosphate.
WebMay 30, 2024 · FIGURE 2.(A) Structural superposition of apo Mab PPAT in complex with feed-back inhibitor CoA (grey), PDB code 7YXZ and product dpCoA (green), PDB code 5O08, showing conformational differences in the enzyme and ligand binding mode.(B) The pantetheine moiety of CoA adopts a similar conformation to that of dpCoA. However, the … WebProteomics of Streptococcus mutans to Reveal the Antibiofilm Formation Mechanism of Ag/ZnO Nanocomposites with Light-Emitting Diode Radiation
WebPhosphopantetheine-binding protein (Pectobacterium carotovorum PC1) - STRING interaction network Nodes: Network nodes represent proteins splice isoforms or post …
WebPhosphopantetheine adenylyltransferase (PPAT, EC. 2.7.7.3) catalyzes an essential step in the reaction that transfers an adenylyl group from adenosine tri phosphate (ATP) to 4' … connecting rcazzr speakersWebFeb 9, 2024 · Binding poses of the natural substrates 4′-phosphopantetheine (PPSH) and ATP are shown for comparison. C) Hydrogen-bonding interactions and hydrophobic interactions (HI) (both represented by dashed lines) between benzophenone 6 and Mtb PPAT. D) Conformational changes observed upon binding of benzophenone 6 to Mtb PPAT. edinburgh doctoral college scholarshipsWebNov 4, 2024 · tyrosine-protein kinase is fine as a protein name but capsular polysaccharide biosynthesis would be more appropriate as a function. RimM protein, required for 16S … connecting react with nodeWebFeb 1, 2024 · The reaction mechanism of PPAT involves a nucleophilic attack by 4′-phosphate of phosphopantetheine on the α-phosphate of ATP in an in-line displacement … connecting react to backendWebJul 21, 2024 · The phosphopantetheine-binding domain (PP-binding superfamily), conserved in ACP proteins, is the prosthetic group of ACP, which acts as a linker for the attachment of the activated FA and amino acid groups via a phosphodiester bond ( Crawford et al. 2008; Meier et al. 2010; Roujeinikova et al. 2002 ). edinburgh dock shipWebThe OUROBOROS and SAMSARA proteins heterodimerise in a similar manner to TALE HD TF life cycle regulators in the green lineage. These observations demonstrate that TALE-HD-TF-based life cycle regulation systems have an extremely ancient origin, and that these systems have been independently recruited to regulate sporophyte developmental ... connecting rca cables to computerWebOct 15, 2012 · Crystal Structure of Free-Standing Peptidyl Carrier Protein from Uncharacterized Acinetobacter baumannii Secondary Metabolic Pathway. ... PHOSPHOPANTETHEINE BINDING PROTEIN; Organism(s): Acinetobacter baumannii AB307-0294; ... Phosphopantetheine attachment site family protein: A, B: 88: … edinburgh docks boat