WebIt is concluded that alpha7 nAChRs negatively control CD40-mediated B lymphocyte proliferation but did not affect the IgM-IgG class switch or memory B cell activation. … WebWhen the groups were pretreated with alpha7-nAChR antagonist, the alpha7-nAChR, cleaved caspase-3, and Bax protein expression increased, but the expression of p-AKT, PI3K, and Bcl-2...
Alpha7 nicotinic receptor up-regulation in cholinergic …
WebAnimals were euthanatized at various post-TBI time intervals, ranging from 1 h to 21 days, and quantitative autoradiography was used to evaluate cholinergic receptor subtype expression in the cerebral cortex and hippocampus. As previously reported, the alpha7* nAChr was the most sensitive target of TBI-induced plasticity. The alpha-7 nicotinic receptor, also known as the α7 receptor, is a type of nicotinic acetylcholine receptor implicated in long-term memory, consisting entirely of α7 subunits. As with other nicotinic acetylcholine receptors, functional α7 receptors are pentameric [i.e., (α7)5 stoichiometry]. It is located in the brain, … See more Recent work has demonstrated a potential role in reducing inflammatory neurotoxicity in stroke, myocardial infarction, sepsis, and Alzheimer's disease. An α7 nicotinic agonist appears to have positive effects on … See more Agonists • (+)-N-(1-azabicyclo[2.2.2]oct-3-yl)benzo[b]furan- 2-carboxamide: potent and highly subtype-selective • Tilorone. • A-582941: partial agonist; activates ERK1/2 and CREB phosphorylation; enhances cognitive performance See more • α3β2-Nicotinic receptor • α3β4-Nicotinic receptor • α4β2-Nicotinic receptor • RIC3, a chaperone protein for α7 receptors See more rajasthan blog
Activation of α7-nAChRs protects SH-SY5Y cells from 1-methyl-4 ...
WebFeb 5, 2024 · Sepsis-induced neuromuscular dysfunction results from up-regulation of the expression of γ- and α7-nicotinic acetylcholine receptors (nAChR). Although glial cell … WebExpression levels of alpha7 nAChRs were inversely associated with Global Cognitive Score and with Mini-Mental State Examination performance. Conclusions: Alternatively, … Webalpha7 nAChR may play an important role in neuropathology caused by gp120. These findings demonstrate that a7nAChR plays an important role in H1299 cell proliferation, … dr bu o\\u0027brien