Ctgf tumor

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August undefined, 2024

WebIn pancreatic cancer, CTGF is a critical regulator of tumor growth, and CTGF-specific antibody attenuates tumor growth and metastases in vivo [7, 8]. On the other hand, increased CTGF expression has been correlated with improved prognosis in chondrosarcoma patients and in patients with lung cancer [ 9 , 10 ]. WebJun 3, 2013 · Background The role of CTGF varies in different types of cancer. The purpose of this study is to investigate the involvement of CTGF in tumor progression and prognosis of human nasopharyngeal carcinoma (NPC). Experimental design CTGF expression levels were examined in NPC tissues and cells, nasopharynx (NP) tissues, and NP69 cells. The …

Targeting CTGF in Cancer: An Emerging Therapeutic Opportunity

WebAug 27, 2014 · (A) Fibroblasts were purified from Myc-CaP tumors 1 wk after sham operation or castration (C) (n = 10 per group), plated, and stimulated for 24 h with TGF-β1 (10 ng/mL), CTGF (50 ng/mL), or TGF-β1 plus CTGF. RNA was isolated, and expression of the indicated genes was analyzed as described earlier. WebMar 3, 2004 · Connective tissue growth factor (CTGF), a secreted protein that binds to integrins, modulates the invasive behavior of certain human cancer cells, but few mechanistic details are known. We investigated the roles of CTGF and collapsin response mediator protein 1 (CRMP-1) in metastasis and invasion of human lung adenocarcinoma. designer saree with sleeveless blouse

CTGF Mediates Tumor-Stroma Interactions between …

WebMay 10, 2024 · Our findings suggest that CTGF is a marker for medulloblastoma independent of molecular subgroups and its transcriptional program is active at the … WebMar 10, 2024 · CTGF is overexpressed in triple-negative breast cancer. In a publicly available gene expression database, the Cancer Cell Line Encyclopedia portal, we … WebOct 29, 2024 · Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved in different biological processes, such as cell proliferation, angiogenesis, and wound healing, as well as multiple … designer save the date cards

CTGF expression is indicative of better survival rates in ... - Nature

AMOTL1 enhances YAP1 stability and promotes YAP1-driven …

WebJul 8, 2013 · Accordingly, we investigated the function of connective tissue growth factor (CTGF), a protein known to be important in stromal formation. CTGF is a pleiotropic and cysteine-rich matricellular protein that is abundant in many solid malignancies including pancreas, breast, esophageal, glioblastoma, and hepatocellular carcinoma ( 18 – 23 ). WebFeb 28, 2024 · Results . AuNPs were able to decrease the density of colorectal cancer associated fibroblasts (CAFs), to reduce the production of tumor stromal collagen I, and to diminish the expression of profibrotic signals, including CTGF, TGF-β1 as well as VEGF in vivo and vitro via Akt signaling pathway. chu chu tv for kids youtubeWebApr 20, 2016 · Breast cancer is the most common cancer in women worldwide, and approximately 90% of breast cancer deaths are the result of metastasis. Metastasis is the process by which tumor cells detach from a primary tumor and migrate to nearby blood vessels or the lymph system, and are thereby able to spread to other organs in the host … designers book club

"WebSep 9, 2015 · High expression of CTGF in breast tumor epithelial component correlates with poor clinical prognosis and outcomes. The interaction between tumor and stromal cells and their signaling output mould the microenvironment to support tumorigenesis and metastasis [].In this context, cytokines, chemokines, as well as growth, angiogenesis and … " - Ctgf tumor

Ctgf tumor

Targeting CTGF in Cancer: An Emerging Therapeutic Opportunity

WebApr 20, 2024 · a The efficacies of the first-line anti-cancer drugs (Cisplatin and 5-FU) were assessed on GC cells after knocking down AMOTL1, YAP1, CTGF, and control, respectively. b The IC 50 of VP was ... WebJul 12, 2014 · Connective tissue growth factor (CTGF)/CCN family member 2 (CCN2) is a CCN family member of matricellular signaling modulators. It has been shown that CCN2/CTGF mediates cell adhesion, aggregation and migration in a large variety of cell types, including vascular endothelial cells, fibroblasts, epithelial cells, aortic smooth …

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WebAug 6, 2024 · Connective tissue growth factor (CTGF) is a member of the CCN matricellular protein family, consisting of four domains, that regulates the signaling of other growth factors and promotes kidney fibrosis. ... cancer, and infections. Glomerulonephritis is a common cause of end-stage renal failure. Severe and prolonged inflammation can … WebSep 4, 2024 · Connective tissue growth factor (CTGF) is a matricellular protein related to hepatic fibrosis. This study aims to clarify the roles of CTGF in hepatocellular carcinoma (HCC), which usually develops from fibrotic liver. CTGF was overexpressed in 93 human HCC compared with nontumorous tissues, primarily in tumor cells.

WebApr 7, 2024 · Recently, CTGF was also found to play an important role in the growth of bone metastases from prostate and breast cancer through forming CTGF–Runx2–RANKL axis 37. WebWe examined in detail the molecular mechanisms of MUC1.CT signaling that induces the expression of connective tissue growth factor (CTGF/CCN2), a potent mediator of ECM …

WebSep 12, 2024 · INTRODUCTION. Urothelial bladder cancer (UBC) is a common urinary malignancy. In 2012, about 429,800 new cases and 165,100 deaths arising from UBC occur worldwide [].In the United States, UBC is estimated that to be the second most frequent genitourinary tract cancer and the fourth most common cancer in male in 2024 [].At … WebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast activation protein (FAP) and the connective tissue growth factor (CTGF) can function in tumor-associated stromal cells but are practically inactive in normal adult cells. Accordingly, the …

WebSep 9, 2015 · High expression of CTGF in breast tumor epithelial component correlates with poor clinical prognosis and outcomes. The interaction between tumor and stromal cells …

WebMar 21, 2024 · These eight phenotypes are “TNF- CTGF- GLUT4+”, “TNF- CTGF+ GLUT4-”, “TNF- CTGF+ GLUT4+”, “TNF+ CTGF- GLUT4-”, “TNF+ CTGF- GLUT4+”, “TNF+ CTGF+ GLUT4-”, ... M2 and tumor-associated macrophages (TAMs) type M1 (M1-TAM) and type M2 (M2-TAM) (Figure 1E). Using this computational approach, we found that insulin … designers backgroundWebFeb 2, 2014 · Here, we define connective tissue growth factor (CTGF) as a therapeutic target for metastatic melanoma. Clinically, CTGF expression correlates with tumor progression and is strongly induced by hypoxia through HIF-1 and HIF-2-dependent mechanisms. Genetic inhibition of CTGF in human melanoma cells is sufficient to … chu chu tv hansel and gretelWebSep 15, 2024 · Malignant mesothelioma (MM) is an aggressive mesothelial cell cancer type linked mainly to asbestos inhalation. MM characterizes by rapid progression and resistance to standard therapeutic modalities such as surgery, chemotherapy, and radiotherapy. Our previous studies have suggested that tumor cell-derived connective tissue growth … chuchu tv head shoulders kneesWebConnective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein involved in the control of biological processes, such as cell proliferation, differentiation, adhesion and angiogenesis, as well as multiple pathologies, such as tumor development and tissue fibrosis. chu chu tv head shoulders knees toesWebIncreasing evidence emphasizes the notion that CTGF is pivotal in cancer initiation and progression. The interplay of tumor cells and the tumor microenvironment significantly … designers at paris fashion weekWebJul 18, 2024 · Dynamic interaction between prostate cancer and the bone microenvironment is a major contributor to metastasis of prostate cancer to bone. In this study, we utilized an in vitro co-culture model of PC3 prostate cancer cells and osteoblasts followed by microarray based gene expression profiling to identify previously unrecognized prostate … chuchu tv ice creamWebJun 15, 2012 · Therefore, we investigated whether CTGF modulates metabolism in the tumor microenvironment. For this purpose, CTGF was overexpressed in normal human fibroblasts or MDA-MB-231 breast cancer cells. Overexpression of CTGF induces HIF-1α-dependent metabolic alterations, with the induction of autophagy/mitophagy, … chuchu tv head shoulders knees toes